No.1 Nitric Oxide Expert: Why You’re Always Tired and It’s Not Your Fault

TL;DR

Nitric oxide (NO) is a naturally produced gas that regulates blood flow, oxygen delivery, stem cell mobilization, telomerase activation, and mitochondrial function. Loss of NO production begins around age 30 (10–12% decline per decade) and is the earliest event in age-related chronic diseases including erectile dysfunction, hypertension, diabetes, Alzheimer’s, and exercise intolerance.

Key insights

• The first symptom of NO deficiency is erectile dysfunction (the “canary in the coal mine”), which is actually an accelerated form of cardiovascular disease in both men and women.
• 50% of hypertensive patients do not respond to prescription medications (ACE inhibitors, ARBs, calcium channel blockers) because those drugs do not restore NO production.
• NO is necessary for insulin signaling; NO deficiency causes insulin resistance, linking it to metabolic disease and type 3 diabetes (Alzheimer’s).